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Reaction of Picolinamides with Ketones Producing a New Type of Heterocyclic Salts with an Imidazolidin-4-One Ringстатья
Дата последнего поиска статьи во внешних источниках: 19 июня 2024 г.
- Авторы: Kramarova Eugenia P., Lyakhmun Dmitry N., Tarasenko Dmitry V., Borisevich Sophia S., Khamitov Edward M., Yusupova Alfia R., Korlyukov Alexander A., Romanenko Alexander R., Shmigol Tatiana A., Bylikin Sergey Yu, Baukov Yuri I., Negrebetsky Vadim V.
- Журнал: Molecules
- Том: 29
- Номер: 1
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 206
- DOI: 10.3390/molecules29010206
- Аннотация: Reactions of picolinamides with 1,3-propanesultone in methanol followed by the treatment with ketones led to a series of previously unknown chemical transformations, yielding first pyridinium salts (2a–f), with a protonated endocyclic nitrogen atom, and then heterocyclic salts (3a–j) containing an imidazolidin-4-one ring. The structures of intermediate and final products were determined by IR and 1H, 13C NMR spectroscopy, and X-ray study. The effects of the ketone and alcohol structures on the product yield were studied by quantum-chemical calculations. The stability of salts 3a–j towards hydrolysis and alcoholysis makes them excellent candidates for the search for new types of biologically active compounds.
- Добавил в систему: Романенко Александр Романович