Subthalamic activity in Park2-associated early-onset Parkinson’s disease

Pavlovsky, P.; Filyushkina, V.; Gamaleya, A.; Tomskiy, A.; Belova, E.; Sedov, A.

Авторы: Pavlovsky P., Filyushkina V., Gamaleya A., Tomskiy A., Belova E., Sedov A.
Журнал: Parkinsonism and Related Disorders
Том: 122
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 75
Последняя страница: 75
Номер статьи: 106784
DOI: 10.1016/j.parkreldis.2024.106784
Аннотация: Background: One of the most common forms of early-onset Parkinson’s disease (PD) is Park2, which is associated with mutations in the parkin gene. Though it has been hypothesized that the mutated parkin may lead to specific pathological interplay between the substantia nigra (SNc) and the subthalamic nucleus (STN), little is known about whether the STN activity under this mutation is different from other forms of early-onset PD.Methods: We enrolled eight patients with early-onset Parkinson’s disease (mean onset age = 34 years) in this study. Four of them had a confirmed Park2 mutation, while the others possessed none of the tested PD-associated mutations.All patients underwent microelectrode recording (MER) of subthalamic single unit activity during bilateral DBS implantation surgeries. For the analysis, the recorded neurons were divided into three groups, according to their activity type – i.e., into tonic, burst and pause cells - using a method of hierarchical clustering based on Ward’s algorithm.Results: We found that in Park2 patients all neurons, regardless of their activity type, were characterized by increased coefficient of variation (Cv). In addition to that, burst and pause neurons represent significantly different oscillatory activity between the patient groups. Oscillation scores of both these neurons’ types are lower (p<0.01 by Mann-Whitney U test) in both alpha (8-12 Hz) and low beta (12-20 Hz) bands in Park2 patients.Conclusions: Our results suggest that the Park2 mutation might be characterized by a broadband decrease in alpha-low beta oscillations and by less regular single unit activity in comparison to non-genetic early-onset PD cases. Further research, especially comparison with mutations characterized by slower disease progression, is needed to investigate these findings.The study was funded by the Russian Science Foundation (22-15-00344).
Добавил в систему: Гамалея Анна Александровна

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