The first example of a polyhedral boron derivative of gadolinium(III) phthalocyaninate as a promising prototype of a theranostic agent

Monich, S.V.; Zhdanov, A.P.; Nelyubin, A.V.; Skribitsky, V.A.; Lipengolts, A.A.; Bunin, D.A.; Martynov, A.G.; Zhizhin, K.Y.; Kuznetsov, N.T.; Gorbunova, Y.G.; Yu, T.A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 июля 2024 г.

Авторы: Monich Svetlana V., Zhdanov Andrey P., Nelyubin Alexey V., Skribitsky Vsevolod A., Lipengolts Alexey A., Bunin Dmitry A., Martynov Alexander G., Zhizhin Konstantin Yu, Kuznetsov Nikolay T., Gorbunova Yulia G., Yu Tsivadze Aslan
Журнал: Inorganic Chemistry Communications
Том: 167
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 112820
DOI: 10.1016/j.inoche.2024.112820
Аннотация: We report the first synthesis of a polyhedral boron derivative of gadolinium(III) phthalocyaninate. Initially, reaction of 4-nitrophthalonitrile with 4-formylphenol in the presence of base was carried out to give 4-(4-formylphenoxy)phthalonitrile. This compound was then converted to 4-(4-hydroxymethylphenoxy)phthalonitrile using sodium tris-acetoxy borohydride in THF. Sequential cyclotetramerisation of this semiproduct in the presence of magnesium acetate, treatment of the resulting complex with trifluoroacetic acid, and complexation with gadolinium(III) acetate afforded gadolinium(III) phthalocyanine containing four hydroxymethylphenoxy groups at the peripheral (β) positions. Then, a nucleophilic addition reaction of this complex with acetonitrilium derivative of [B10H10]2- anion afforded gadolinium(III) phthalocyaninate decorated with four closo-decaborate units in good/satisfactory yield. The new product was characterised by various techniques (CHN analysis, MALDI-TOF mass spectrometry and UV–Vis spectroscopy). The boron content in this product is 21.5 wt% (40 atoms), and the r1 relaxivity of the conjugate 6.1 ± 0.7 mM-1s−1 (at 3.0 T, 20 °C in water), which makes it a promising prototype for theranostic agents for MRI-guided BNC therapy in future investigations.
Добавил в систему: Бунин Дмитрий Александрович

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ИНХС РАН

The first example of a polyhedral boron derivative of gadolinium(III) phthalocyaninate as a promising prototype of a theranostic agentстатья

Прикрепленные файлы