Computer Simulations of Responsive Nanogels at Lipid Membrane

Авторы: Sorokina A.S., Gumerov R.A., Noguchi H., Potemkin I.I.
Журнал: Macromolecular Rapid Communications
Том: 45
Год издания: 2024
Издательство: John Wiley & Sons Ltd.
Местоположение издательства: United Kingdom
Номер статьи: 2400406
DOI: 10.1002/marc.202400406
Аннотация: The swelling and collapse of responsive nanogels on a planar lipid bilayer arestudied by means of mesoscopic computer simulations. The effects ofmolecular weight, cross-linking density, and adhesion strength are examined.The conditions for collapse-mediated engulfing by the bilayer are found. Inparticular, the results show that at low hydrophobicity level the increase in thenanogel softness decreases the engulfing rate. On the contrary, for strongerhydrophobicity level the trend changes to the opposite one. At the same time,when the cross-linking density is too low or the adhesion strength is too highthe nanogel deformation at the membrane suppresses the engulfingregardless of the network swelling ratio. Finally, for comparative reasons, thebehavior of the nanogels is also studied at the solid surface. These resultsmay be useful in the design of soft particles capable of tuning of theirelasticity and porosity for successful intracellular drug delivery.
Добавил в систему: Гумеров Рустам Анрикович

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