The genetic landscape of neuro-related proteins in human plasma

Repetto, L.; Chen, J.; Yang, Z.; Zhai, R.; Timmers Paul, R.H.; Feng, X.; Li Ting; Yao, Y.; Maslov, D.; Timoshchuk, A.; Tu, F.; Twait, E.L.; May-Wilson, S.; Muckian, M.D.; Prins, B.P.; Png, G.; Kooperberg, C.; Johansson, Å.; Hillary, R.F.; Wheeler, E.; Pan, L.; He, Y.; Klasson, S.; Ahmad, S.; Peters, J.E.; Gilly, A.; Karaleftheri, M.; Tsafantakis, E.; Haessler, J.; Gyllensten, U.; Harris, S.E.; Wareham, N.J.; Göteson, A.; Lagging, C.; Ikram, M.A.; van Duijn, C.M.; Jern, C.; Landén, M.; Langenberg, C.; Deary, I.J.; Marioni, R.E.; Enroth, S.; Reiner, A.P.; Dedoussis, G.; Zeggini, E.; Sharapov, S.; Aulchenko, Y.S.; Butterworth, A.S.; Mälarstig, A.; Wilson, J.F.; Navarro, P.; Shen, X.

Авторы: Repetto Linda, Chen Jiantao, Yang Zhijian, Zhai Ranran, Timmers Paul R.H.J, Feng Xiao, Li Ting, Yao Yue, Maslov Denis, Timoshchuk Anna, Tu Fengyu, Twait Emma L., May-Wilson Sebastian, Muckian Marisa D., Prins Bram P., Png Grace, Kooperberg Charles, Johansson Åsa, Hillary Robert F., Wheeler Eleanor, Pan Lu, He Yazhou, Klasson Sofia, Ahmad Shahzad, Peters James E., Gilly Arthur, Karaleftheri Maria, Tsafantakis Emmanouil, Haessler Jeffrey, Gyllensten Ulf, Harris Sarah E., Wareham Nicholas J., Göteson Andreas, Lagging Cecilia, Ikram Mohammad Arfan, van Duijn Cornelia M., Jern Christina, Landén Mikael, Langenberg Claudia, Deary Ian J., Marioni Riccardo E., Enroth Stefan, Reiner Alexander P., Dedoussis George, Zeggini Eleftheria, Sharapov Sodbo, Aulchenko Yurii S., Butterworth Adam S., Mälarstig Anders, Wilson James F., Navarro Pau, Shen Xia
Журнал: Nature Human Behaviour
Год издания: 2024
Издательство: Nature Research
Местоположение издательства: London, UK
DOI: 10.1038/s41562-024-01963-z
Аннотация: Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50% of each protein’s heritability. At the cis-pQTL, multiple proteins shared a genetic basis with human behavioural traits such as alcohol and food intake, smoking and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs while suggesting hundreds of repurposing and new therapeutic targets.
Добавил в систему: Тимощук Анна Николаевна

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The genetic landscape of neuro-related proteins in human plasmaстатья