Synthesis and biological activity of N-substitutedtetrahydro-γ- Carbolines containing peptide residuesстатья
Информация о цитировании статьи получена из
Web of Science ,
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 октября 2014 г.
Авторы:
Sokolova N.V.,
Nenajdenko V.G. ,
Sokolov V.B.,
Vinogradova D.V.,
Shevtsova E.F. ,
Dubova L.G.,
Bachurin S.O.
Журнал:
Beilstein Journal of Organic Chemistry
Том:
10
Год издания:
2014
Издательство:
Beilstein-Institut
Местоположение издательства:
Germany
Первая страница:
155
Последняя страница:
162
DOI:
10.3762/bjoc.10.13
Аннотация:
The synthesis of novel peptide conjugates of N-substituted-tetrahydro- γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry. The effect of obtained γ-carboline-peptide conjugates on the rat liver mitochondria was evaluated. It was found that all compounds in the concentration of 30 μM did onot induce depolarization of mitochondria but possessed some inhibitory effect on the mitochondria permeability transition. The original N- substitutedtetrahydro-γ-carbolines containing an terminal alkyne group demonstrated a high prooxidant activity, whereas their conjugates with peptide fragments slightly inhibited both autooxidation and the t-BHP-induced lipid peroxidation. © 2014 Sokolova et al; licensee Beilstein-Institut.
Добавил в систему:
Ненайденко Валентин Георгиевич