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Comparison of Molecular Genetic Mechanisms of Response to Heat and Cold Stresses in Drosophila melanogasterстатья
- Авторы: Neizvestny D.S., Yakovleva E.Y.
- Журнал: Biology Bulletin Reviews
- Том: 14
- Номер: 5
- Год издания: 2024
- Издательство: Pleiades Pub.
- Местоположение издательства: Tortola, British Virgin Islands, British Virgin Islands
- Первая страница: 548
- Последняя страница: 560
- DOI: 10.1134/S2079086424700026
- Аннотация: Molecular mechanisms of stress response are interesting from an evolutionary point of view, since they are often under the influence of natural selection. In this study, a review of molecular mechanisms of response to temperature stresses was carried out by the example of a model organism Drosophila melanogaster, in which these mechanisms were studied in some detail. The responses to heat and cold stress were compared, and similar and specific molecular mechanisms of response to them were identified. An increase in the expression of heat shock proteins (HSP) genes and Turandot family genes and the activation of serine-threonine protein kinase p38 MAPK are key processes common to responses to both types of stress. Under a heat stress, TORC2-mediated formation of stress granules is also observed; under cold stress, an increase in the synthesis of the calcium-binding protein DCA and cryoprotective protein FROST is observed. Some similarity in responses to heat and cold stress can be explained by a similar nature of the observed damage and multifunctionality of the proteins providing stress responses. It is likely that there is an evolutionary trade-off between tolerance to heat and cold stress in D. melanogaster: an increase in resistance to one stress leads to a decrease in resistance to another one. Drosophila at different stages of the life cycle demonstrate different sensitivity to temperature effects, and the mechanisms of response to them are also partially different. A comparison of the results of the studies devoted to evolution of the proteins involved in the response to temperature stress makes it possible to conclude that these molecular mechanisms are rapidly evolving in insects, and the conclusions obtained on D. melanogaster should be transferred to other animals (even within the order Diptera) with a great caution. In conclusion, using the FlyBase database, a localization of the genes whose products are involved in the response to temperature stress in the Drosophila genome was established. Fifteen out of 21 genes discussed in the work are located on the third chromosome, 10 of them on its right arm; this makes it possible to put forward a hypothesis about the adaptive convergence of the genes whose proteins are involved in the stress response in the D. melanogaster genome. This probably makes it possible to synchronize more accurately the regulation of their expression. Understanding the molecular mechanisms of insect response to temperature stresses can have a practical importance: help to predict changes in the ranges of individual species and their adaptation to rapidly changing climatic conditions, as well as contribute to the development of insecticides making it possible to resist insect pests of agricultural crops and invasive species.
- Добавил в систему: Яковлева Екатерина Юрьевна