Synthesis and characterization of novel amphiphilic copolymers of N-vinyl-2-pyrrolidone and oleic acid

Koziavina, D.A.; Nechaeva, A.M.; Belousova, V.A.; Vnukova, A.A.; Bagrov, D.V.; Mezhuev, Y.O.

Авторы: Koziavina D.A., Nechaeva A.M., Belousova V.A., Vnukova A.A., Bagrov D.V., Mezhuev Y.O.
Сборник: XIII International Conference on Chemistry for Young Scientists “MENDELEEV 2024”
Тезисы
Год издания: 2024
Место издания: VVM Publishing LLC St Petersburg
Первая страница: 215
Аннотация: Modern drug delivery systems are capable of enhancing the bioavailability of hydrophobicdrugs, thereby increasing their efficacy and minimizing toxicity. These properties make drug deliverysystems (DDS) one of the key research objects of chemical and pharmaceutical sciences. Amphiphilicpolymeric macromolecules based on biocompatible substances are of particular interest for thecreation of such systems. [1-2]. Amphiphilic polymeric macromolecules are capable of self-assemblyin an aqueous environment, resulting in the formation of aggregates with a hydrophobic core and ahydrophilic shell. This enables them to immobilize a wide range of drugs. Therefore, the synthesis ofsuch compounds represents an important task.In this study, amphiphilic copolymers of N-vinyl-2-pyrrolidone and oleic acid have beensynthesized and characterized. Poly-N-vinyl-2-pyrrolidone is a highly biocompatible, non-immunogenic, low-toxic and water-soluble polymer, rendering it a promising basis for drug deliverysystems [3]. Oleic acid, in turn, is a non-toxic natural compound containing a long hydrocarbon radicalthat imparts hydrophobicity to the copolymer molecule. The structure of the synthesized copolymerswas confirmed by 13C and 1H NMR spectroscopy, and the aggregation processes of amphiphilicmacromolecules were investigated by dynamic light scattering and tensiometry.Scheme 1. Formation of amphiphilic copolymer of N-vinyl-2-pyrrolidone and oleic acidThe use of dynamic laser light scattering (DLS) and tensiometry methods has demonstratedthat amphiphilic copolymers of N-vinyl-2-pyrrolidone and oleic acid undergo self-assembly in aqueoussolution to form aggregates with average hydrodynamic diameters in the nanoscale range (120-270nm). The effect of the monomeric composition on the critical concentration of aggregation and the sizeof aggregates has been shown. The aggregates exhibited a narrow diameter distribution and aspherical shape, as evidenced by transmission electron microscopy (TEM) data. It has beendemonstrated that aggregates of amphiphilic macromolecules are capable of binding the model drugcurcumin through hydrophobic interactions. Therefore, the synthesized amphiphilic copolymers are ofinterest for the development of new drug delivery platforms.
Добавил в систему: Внукова Анна Александровна

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ИНХС РАН

Synthesis and characterization of novel amphiphilic copolymers of N-vinyl-2-pyrrolidone and oleic acidтезисы доклада

Прикрепленные файлы