|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Bifunctional Copper Chelators Capable of Reducing Aβ Aggregation and Aβ-Induced Oxidative Stressстатья Исследовательская статья
- Авторы: Krasnovskaya Olga, Abramchuk Daniil, Vaneev Alexander, Gorelkin Petr, Abakumov Maxim, Timoshenko Roman, Kuzmichev Ilia, Chmelyuk Nelly, Vadehina Veronika, Kuanaeva Regina, Dubrovin Evgeniy, Kolmogorov Vasilii, Beloglazkina Elena, Kechko Olga, Mitkevich Vladimir, Varshavskaya Kseniya, Salikhov Sergey, Erofeev Alexander
- Журнал: ACS Omega
- Год издания: 2024
- DOI: 10.1021/acsomega.4c03152
- Аннотация: Five bifunctional copper chelating agents, Alz-(1–5), designed to prevent beta-amyloid (Aβ) aggregation, were synthesized, and the leader compound (Alz-5) was chosen. Alz-5 acts as a bifunctional chelator that can interact with various Aβ aggregates and reduce their neurotoxicity. Reactive oxygen species measurements provided by the Pt-nanoelectrode technique in single Aβ42-affected human neuroblastoma SH-SY5Y cells revealed significant antioxidant activity of Alz-5. AFM data obtained on Aβ42 fibrils clearly indicate the antiaggregating property of Alz-5. To gain insights into the changes in the physiomechanical properties of Aβ42-affected cells, as well as in order to evaluate the antiaggregating ability of Alz-5, Young’s modulus mapping on living SH-SY5Y cells affected consequently by Aβ42 and Alz-5 was conducted, and the ability of Alz-5 to decrease cell rigidity induced by Aβ42 was indisputably proven. Low cell toxicity and antioxidating properties, in conjunction with AFM and SICM-based biophysical provided on Aβ42-affected SH-SY5Y cells, support Alz-5 as a potential inhibitor of Aβ aggregation.
- Добавил в систему: Ванеев Александр Николаевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Полный текст (опубликованный вариант) | Bifunctional_Copper_Chelators_Capable_of_Reducing_Aβ_Aggreg… | 7,1 МБ | 19 ноября 2024 [dve2] |
| 2. | Полный текст | krasnovskaya-et-al-2024-bifunctional-copper-chelators-capab… | 6,9 МБ | 18 октября 2024 [Vaneev_AN] | |
| 3. | Экспертное заключение | CamScanner_14.11.2024_12.09.pdf | 694,6 КБ | 14 ноября 2024 [Krasnovskaya_Olga] |