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Changes in the Cyto-and Fibroarchitectonics of the Cerebellar Cortex in Rats Subjected to Extreme Physical Activityстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Balakin E., Yurku K., Kuropatkin V., Izotov A., Nakhod V., Pustovoyt V.
- Журнал: Biology
- Том: 13
- Номер: 840
- Год издания: 2024
- Издательство: MDPI Publishing
- Местоположение издательства: Basel, Switzerland, Switzerland
- Первая страница: 840
- Последняя страница: 10
- DOI: 10.3390/biology13100840
- Аннотация: Physical overexertion surpassing the functional capacity of the nervous system causesthe hyperactivation of the neural structures of the cerebellum. In turn, it causes the depletionof intracellular resources and progressive structural changes in cerebellar cells and fibers. Thesedegenerative changes may lead to cerebellar dysfunction, including the worsening of coordination,balance, and motor functions. In order to maintain the health and functioning of the cerebellumand the nervous system in general, one needs to avoid physical overexertion and have enough timeto recover. Three major types of Purkinje cells were identified in control group animals. After theforced swimming test, animals had significant morphological changes in pyriform cells, granule cells,internuncial neurons, and neuroglial cells. In particular, the extreme degeneration of granule cells wasmanifested via their fusion into conglomerates. These changes demonstrate that neurodegenerationin the cerebellum takes place in response to physical overexertion.
- Добавил в систему: Пустовойт Василий Игоревич