Human prothymosin alpha inhibits division of yeast Saccharomyces cerevisiae cells, while its mutant lacking nuclear localization signal does notстатья
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Дата последнего поиска статьи во внешних источниках: 31 октября 2014 г.
Авторы:
Pavlov N.,
Evstafieva A.,
Rubtsov Y.,
Vartapetian A.
Аннотация:Effect of human prothymosin alpha and its mutant over-produced in S. cerevisiae on yeast cell division was studied. Wild-type prothymosin alpha appeared to block division of yeast cells. Its inhibitory action could be abolished by deletion of the last nine carboxy-terminal amino acids of prothymosin alpha containing nuclear localization signal, thus pointing to the nucleus as a compartment, where prothymosin alpha performs its action.