Vimentin Intermediate Filaments Maintain Membrane Potential of Mitochondria in Growing Neurites. Biology, издательство MDPI

Авторы: Dayal A.A., Parfenteva O.I., Wang H., Gebreselase B.A., Gyoeva F.K., Alieva I.B., Minin A.A.
Журнал: Biology
Том: 13
Номер: 12
Год издания: 2024
Издательство: MDPI Publishing
Местоположение издательства: Basel, Switzerland, Switzerland
Первая страница: 995
DOI: 10.3390/biology13120995
Аннотация: Vimentin, a type III protein of intermediate filaments (IFs) characteristic of mesenchymal cells, was found in neural cells, together with neurofilaments in the early stages of their differentiation or recovery after damage. Since in the fibroblasts, vimentin IFs were implicated in the maintenance of mitochondrial membrane potential, we decided to explore their possible impact on the mitochondria in neural cells. The CAD cell line offers a convenient model to investigate neuritogenesis, which is stimulated by the simple removal of serum from the culture medium. The results of this study show that, indeed, the deletion of vimentin in these cells led to adecrease in the membrane potential of mitochondria, though other IFs and neurofilaments remained. Furthermore, the restoration of vimentin IFs in the knockout cell line by the humanvimentin caused an increase in the mitochondrial potential.
Добавил в систему: Алиева Ирина Борисовна

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА