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Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cellsстатья
- Авторы: Antipova T.A., Deev I.E., Gudasheva T.A., Nikolaev S.V., Logvinov I.O., Serova O.V., Gavrilenkova A.A., Povarnina P.Yu, Tarasiuk A.V., Vakhitova Yu V., Seredenin S.B.
- Журнал: Pharmaceutical Chemistry Journal
- Том: 56
- Номер: 12
- Год издания: 2023
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 1568
- Последняя страница: 1572
- DOI: 10.1007/s11094-023-02828-x
- Аннотация: TrkA and TrkB knockout HT-22 cell lines were used to prove that the neuroprotective properties of GK-2 [bis(N-monosuccinyl-L-glutamyl-L-lysine hexamethylenediamide], a low-molecular-weight dipeptide mimetic of the NGF 4th loop, are definitely mediated by selective interaction with TrkA receptor upon oxidative stress-induced cellular damage in vitro.
- Добавил в систему: Николаев Сергей Владимирович