|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
The synthesis and antiproliferative activity of isatin-7-sulfonamidesстатья Исследовательская статья
- Авторы: Krymov Stepan K., Salnikova Diana I., Dezhenkova Lyubov G., Bogdanov Fedor B., Scherbakov Alexander M., Shchekotikhin Andrey E.
- Журнал: Chemistry of Heterocyclic Compounds
- Том: 60
- Номер: 9/10
- Год издания: 2024
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 473
- Последняя страница: 479
- DOI: 10.1007/s10593-024-03365-5
- Аннотация: Varying the position of the pharmacophore group in a heterocyclic ring can have a significant effect on the biological activity of compounds. By means of the formamidine protecting group and the Sandmeyer reaction, a route of synthesis of previously undescribed isatin-7-sulfonamides was developed. The synthesized 1-substituted isatin-7-sulfonamides inhibited the growth of hematological and solid tumor cells in low micromolar concentrations. The obtained data indicate the promise of 1-substituted isatin-7-sulfonamides as a new pharmacophore for the development of compounds with antitumor activity.Keywords: formamidine protecting group, isatin, sulfonamides, antiproliferative activity, Sandmeyer reaction
- Добавил в систему: Сальникова Диана Игоревна