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Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 января 2025 г.
- Авторы: Zhao Ruiwen, Sukocheva Olga, Tse Edmund, Neganova Margarita, Aleksandrova Yulia, Zheng Yufei, Gu Hao, Zhao Deyao, Madhunapantula SabbaRao V., Zhu Xiaorong, Liu Junqi, Fan Ruitai
- Журнал: Cell Communication and Signaling
- Том: 22
- Номер: 1
- Год издания: 2024
- Издательство: BioMed Central
- Местоположение издательства: London
- Номер статьи: 379
- DOI: 10.1186/s12964-024-01743-2
- Аннотация: Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the development of various diseases, including cancer. Notably, copper-induced cell death was defined as cuproptosis which was also observed in malignant cells, representing an attractive anti-cancer instrument. Excess of intracellular copper leads to the aggregation of lipoylation proteins and toxic stress, ultimately resulting in the activation of cell death. Differential expression of cuproptosis-related genes was detected in normal and malignant tissues. Cuproptosis-related genes were also linked to the regulation of oxidative stress, immune cell responses, and composition of tumor microenvironment. Activation of cuproptosis was associated with increased expression of redox-metabolism-regulating genes, such as ferredoxin 1 (FDX1), lipoic acid synthetase (LIAS), lipoyltransferase 1 (LIPT1), dihydrolipoamide dehydrogenase (DLD), drolipoamide S-acetyltransferase (DLAT), pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1), and pyruvate dehydrogenase E1 subunit beta (PDHB)). Accordingly, copper-activated network was suggested as an attractive target in cancer therapy. Mechanisms of cuproptosis and regulation of cuproptosis-related genes in different cancers and tumor microenvironment are discussed in this study. The analysis of current findings indicates that therapeutic regulation of copper signaling, and activation of cuproptosis-related targets may provide an effective tool for the improvement of immunotherapy regimens.
- Добавил в систему: Александрова Юлия Романовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | s12964-024-01743-2.pdf | 2,1 МБ | 13 января 2025 [AleksandrovaYuR] | |
| 2. | Экспертное_заключение_Signaling.pdf | Экспертное_заключение_Signaling.pdf | 564,6 КБ | 13 января 2025 [AleksandrovaYuR] |