A General Route to 3-Thiosubstituted Steroids via Copper-Catalyzed C–S Coupling

Авторы: Parulava Mikhail J., Kotovshchikov Yury N., Latyshev Gennadij V., Sokolova Darina V., Lukashev Nikolay V., Beletskaya Irina P.
Журнал: SYNTHESIS-STUTTGART
Том: 57
Номер: 8
Год издания: 2025
Издательство: Georg Thieme Verlag
Местоположение издательства: Germany
Первая страница: 1481
Последняя страница: 1489
DOI: 10.1055/a-2520-0317
Аннотация: A convenient and efficient approach to 3-thiosubstituted androstanes has been developed. The formation of a C(sp2)–S bond was achieved through the Cu-catalyzed coupling of steroidal iododienes with a variety of S-nucleophiles, such as (het)aryl thiols and dithiocarbamates. A simple catalytic system comprising CuI without auxiliary ligands enabled the preparation of a library of target compounds in good to high yields. A moderate inhibitory activity against hormone-dependent cancer cell lines was demonstrated for representative 3-thiolated steroids.
Добавил в систему: Котовщиков Юрий Николаевич

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