|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Green Light Activated Dual‐Action Pt(IV) Prodrug With Enhanced PDT activityстатья
- Авторы: Krasnovskaya Olga O., Spector Daniil, Bykusov Vladislav, Isaeva Yulia, Grishin Yuri, Akasov Roman, Zharova Anastasia, Rodin Igor, Kuzmin Vladimir, Vokuev Mikhail, Nikitina Vita, Martynov Alexander, Beloglazkina Elena
- Журнал: ChemMedChem
- Год издания: 2025
- Издательство: Wiley - V C H Verlag GmbbH & Co.
- Местоположение издательства: Germany
- DOI: 10.1002/cmdc.202400786
- Аннотация: ight induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt-based chemotherapeutic drugs. A combination of light-controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt-based chemotherapy and PDT via a synergetic effect. Herein we report green-light-activated Pt(IV) prodrug GreenPt with BODIPY-based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability. GreenPt demonstrated the ability to release cisplatin under low-dose green light irradiation up to 1 J/cm2. The investigation of the photoreduction mechanism of GreenPt prodrug using DFT modeling and ΔG0 PET estimation revealed that the anion-radical formation and substituent photoinduced electron transfer from the triplet excited state of the BODIPY axial ligand to the Pt(IV) center is the key step in the light-induced release of cisplatin. Green-light-activated BODIPY-based photosentitizers 5 and 8 demonstrated outstanding photosensitizing properties with an extraordinary phototoxicity index (PI) >1300. GreenPt prodrug demonstrated gradual intracellular accumulation and light-induced phototoxicity with PI > 100, thus demonstrating dual action through light-controlled release of both cisplatin and a potent BODIPY-based photosensitizer.
- Добавил в систему: Красновская Ольга Олеговна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | CamScanner_21.01.2025_14.37.pdf | CamScanner_21.01.2025_14.37.pdf | 902,9 КБ | 21 января 2025 [Krasnovskaya_Olga] | |
| 2. | Полный текст | ChemMedChem_-_2025_-_Krasnovskaya_-_Green_Light_Activated_D… | 1,6 МБ | 21 января 2025 [Krasnovskaya_Olga] |