Fluorescence-Based Artemisinin Sensing Using Pyronin B-Doped Cellulose Film Reconstituted from Ionic Liquidстатья
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Дата последнего поиска статьи во внешних источниках: 2 сентября 2018 г.
Аннотация:The first use of a cellulose hydrogel film reconstituted from ionic liquid 1-butyl-3-methylimidazolium chloride for the fluorescent determination of a plant antimalarial endoperoxide artemisinin is reported. The sensing material was fabricated by non-covalent co-immobilization of the fluorescent cationic dye pyronin B and complex of Mn(II) with anionic surfactant sodium dodecyl sulfate into the cellulose film. Artemisinin determination in a concentration range of 0.25–8 μM is based on dynamic quenching of pyronin B fluorescence (em/ex = 581/355 nm) that is accelerated by the above-indicated complex. The developed disposable cellulose film exhibits a high sensitivity towards artemisinin (limit of detection – 30 nM), sufficient selectivity for pharmaceutical analysis, a rapid response time (30 s), and a strong stable fluorescent signal for over a month. The applicability of the cellulose film was demonstrated while analyzing a dietary supplement with an extract from the traditional Chinese herb Artemisia annua.