Synthesis, structure and characterization of carbonate substituted hydroxyapatite for bioresorbable materials development

Klimashina, E.S.; Putlayev, V.I.

Авторы: Klimashina E.S., Putlayev V.I.
Сборник: 9th World Biomaterials Congress, China, Chengdu, June 1-5
Серия: Volume 1
Тезисы
Год издания: 2012
Первая страница: 1846
Последняя страница: 1848
Аннотация: With the use of calcium phosphate in medicine, concept of biomaterials application has undergone major changes. Regenerative approach requires accelerating healing process, stimulation of osteosynthesis and substitution of the material with bone tissue de novo, while strength properties seem to be less important since mechanical stresses can be excluded for the period of treatment. In present work an approach to control the resorption rate of a HA-biomaterial is based on its anionic and cationic substitution. Carbonate and sodium modified hydroxyapatite (CHA) was a subject of the work. Carbonate content increasing leads both to rising of solubility the material (and, therefore, to resorption increase) and to significant impact on energetics of osteosynthesis, since the processes of respiration in bone tissue are sufficiently anaerobic (glycolysis). Development of novel resorbable materials is restricted by a number of challenges in chemistry of CHA, related both to direct synthesis of fine-powdered carbonate hydroxyapatite, and to its consolidation into a bulk material. CHA, like other carbonate salts, decomposes with release of CO2 at high temperature, therefore, the use of conventional solid-state sintering is unpromising. Alternative methods of consolidation (e.g., liquid-phase sintering or formation of CHA/(thermoplastic) polymer composites) are to be considered.
Добавил в систему: Климашина Елена Сергеевна

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