Resistive Method for Bacterial Detection Employing a Silicon Nanowire Electrical Chip

Ilin, A.S.; Martyshov, M.N.; Gusev, D.V.; Rusakov, D.M.; Nazarovskaia, D.A.; Domnin, P.A.; Wang, M.; Tsiniaikin, I.I.; Gonchar, K.A.; Ermolaeva, S.A.; Osminkina, L.A.; Forsh, P.A.

Авторы: Ilin Alexander S., Martyshov Mikhail N., Gusev Dmitrii V., Rusakov Daniil M., Nazarovskaia Daria A., Domnin Pavel A., Wang Mengyuan, Tsiniaikin Ilia I., Gonchar Kirill A., Ermolaeva Svetlana A., Osminkina Liubov A., Forsh Pavel A.
Журнал: Biotechnology and Bioengineering
Том: 122
Номер: 6
Год издания: 2025
Издательство: Wiley - V C H Verlag GmbbH & Co.
Местоположение издательства: Germany
Первая страница: 1554
Последняя страница: 1560
DOI: 10.1002/bit.28955
Аннотация: There is now an urgent need to develop reliable, rapid, and cost-effective methods for bacterial detection, particularly for point-of-care applications. This study explores the unique properties of silicon nanowire (SiNW) arrays as a resistive sensing platform for detecting Listeria innocua. Vertically aligned SiNWs, fabricated via metal-assisted chemical etching, exhibited high sensitivity to bacterial adsorption. Conductance measurements revealed a more than 10-fold increase as bacterial concentrations rose from 105 to 107 CFU/mL, with clear saturation at higher levels. The study employed both direct current (DC) and alternating current (AC) methodologies, with AC conductance consistently outperforming DC due to reduced potential barrier effects. An equivalent circuit model was developed to describe the impedance behavior of the SiNW-bacteria system, offering valuable insights into charge transport mechanisms. These results demonstrate the potential of SiNW-based sensors as robust, scalable, and high-performance diagnostic tools. Beyond bacterial detection, the proposed platform offers promising applications in clinical diagnostics, environmental monitoring, and food safety.
Добавил в систему: Гусев Дмитрий Владимирович

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Resistive Method for Bacterial Detection Employing a Silicon Nanowire Electrical Chipстатья Исследовательская статья Электронная публикация

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