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Positioning of sperm tail longitudinal columns depend on Nsun7, an RNA binding protein destabilizing elongated spermatid transcriptsстатья Исследовательская статья
- Авторы: Guseva Ekaterina, Averina Olga, Isaev Sergey, Pletnev Philipp, Bragina Elizaveta, Permyakov Oleg, Buev Vitaly, Priymak Anastasia, Emelianova Mariia, Pshanichnaya Lizaveta, Romanov Evgeny, Novikova Svetlana E., Petriukov Kirill, Golovina Anna, Grigorieva Olga, Manskikh Vasily, Korshunova Diana, Silaeva Yuliya, Deykin Alexey, Rubtsova Maria, Zgoda Victor, Mazur Alexander, Prokhortchouk Egor, Dontsova Olga, Sergiev Petr V.
- Журнал: RNA
- Год издания: 2025
- Первая страница: rna.080320.124
- Последняя страница: rna.080320.124
- DOI: 10.1261/rna.080320.124
- Аннотация: Spermatozoid’s flagella assemble in transcriptionally silent spermatids and thus depends on post-transcriptional regulation of gene expression. Mutations in Nsun7 gene are known to cause male infertility in human and mice. We identified m5C-specific Nsun7 RNA methyltransferase as a protein present in elongated spermatids and interacting with RNAs specific for this type of spermatozoid’s precursor cells. Inactivation of Nsun7 gene in mice leads to upregulation of its RNA interactors, thus indicating that Nsun7 downregulates a set of RNAs in the elongated spermatids. A physiologic consequence of Nsun7 gene knockout is male infertility, which is mechanistically explained by the observed mispositioning of longitudinal columns relative to the axonemal microtubular doublets leading to motility defect.
- Добавил в систему: Гусева Екатерина Алексеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Экспертное заключение | Expert_report.pdf | 632,8 КБ | 4 марта 2025 [eguseva98] | |
| 2. | Полный текст | NSUN7_RNA_full_manuscript.pdf | 864,0 КБ | 3 марта 2025 [eguseva98] |