Remodeling sensory cortical maps implants specific behavioral memoryстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 сентября 2017 г.
Аннотация:Neural mechanisms underlying the capacity of
memory to be rich in sensory detail are largely unknown.
A candidate mechanism is learning-induced plasticity that
remodels the adult sensory cortex. Here, expansion in the
primary auditory cortical (A1) tonotopic map of rats was
induced by pairing a 3.66-kHz tone with activation of the
nucleus basalis, mimicking the effects of natural associative
learning. Remodeling of A1 produced de novo specific
behavioral memory, but neither memory nor plasticity was
consistently at the frequency of the paired tone, which typically
decreased in A1 representation. Rather, there was a
specific match between individual subjects’ area of expansion
and the tone that was strongest in each animal’s memory,
as determined by post-training frequency
generalization gradients. These findings provide the first
demonstration of a match between the artificial induction
of specific neural representational plasticity and artificial
induction of behavioral memory. As such, together with
prior and present findings for detection, correlation and
mimicry of plasticity with the acquisition of memory, they
satisfy a key criterion for neural substrates of memory. This
demonstrates that directly remodeling sensory cortical
maps is sufficient for the specificity of memory formation.