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Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone lossстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 ноября 2014 г.
- Авторы: Maurel D.B., Pallu S., Jaffre C., Fazzalari N.L., Boisseau N., Uzbekov R., Benhamou C.L., Rochefort G.Y.
- Журнал: Alcohol and Alcoholism
- Том: 47
- Номер: 4
- Год издания: 2012
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 413
- Последняя страница: 422
- DOI: 10.1093/alcalc/ags057
- Аннотация: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss.\ After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels.\ These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ’bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.
- Добавил в систему: Узбеков Рустем Эдуардович