Consolidation and long term retention of an implanted behavioral memoryстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 19 сентября 2017 г.
Аннотация:Hypothesized circuitry enabling information storage can be tested by attempting to implant memory
directly in the brain in the absence of normal experience. Previously, we found that tone paired with activation
of the cholinergic nucleus basalis (NB) does induce behavioral memory that shares cardinal features
with natural memory; it is associative, highly specific, rapidly formed, consolidates and shows
intermediate retention. Here we determine if implanted memory also exhibits long-term consolidation
and retention. Adult male rats were first tested for behavioral responses (disruption of ongoing respiration)
to tones (1–15 kHz), yielding pre-training behavioral frequency generalization gradients. They next
received 3 days of training with a conditioned stimulus (CS) tone (8.0 kHz, 70 dB, 2 s) either paired (n = 7)
or unpaired (n = 6) with moderate electrical stimulation of the nucleus basalis (65 lA, 100 Hz, 0.2 s, coterminating
with CS offset). Testing for long-term retention was performed by obtaining post-training
behavioral frequency generalization gradients 24 h and 2 weeks after training. At 24 h post-training,
the Paired group exhibited specific associative behavioral memory, manifested by larger responses to
the CS frequency band than the Unpaired group. This memory was retained 2 weeks post-training. Moreover,
2 weeks later, the specificity and magnitude of memory had become greater, indicating that the
implanted memory had undergone consolidation. Overall, the results demonstrate the validity of NBimplanted
memory for understanding natural memory and that activation of the cholinergic nucleus
basalis is sufficient to form natural associative memory.