Muscarinic dependence of nucleus basalis induced conditioned receptive field plasticityстатья
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Дата последнего поиска статьи во внешних источниках: 19 сентября 2017 г.
Аннотация:Receptive ®eld (RF) plasticity in primary auditory cortex of
adult animals, speci®cally selective increased response to a
tonal conditioned stimulus (CS) relative to other frequencies,
can be induced both by behavioral conditioning and by pairing a
tone with stimulation of the nucleus basalis (NB). This study
determined whether cortical muscarinic receptors are necessary
for NB-induced RF plasticity. Single units in layers II±IV
were studied in Urethane anesthetized adult rats. The cortex
was perfused with saline or salineatropine sulfate. Conditioning,
30 trials of pairing a tone with NB stimulation,
produced a signi®cant CS-speci®c response increase (n8).
Local atropine blocked NB-induced RF plasticity, actually
resulting in CS-speci®c response decrease (n6). Therefore,
NB-induced RF plasticity requires engagement of muscarinic
receptors in auditory cortex.