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Increasing the Accumulation of Modular Nanotransporters in Mouse Tumors by Attaching Polyethylene Glycol to These Nanotransporters with the Possibility of Its Release into the Tumorsстатья
- Авторы: Khramtsov Yu V., Ulasov A.V., Slastnikova T.A., Georgiev G.P., Sobolev A.S.
- Журнал: Doklady Biochemistry and Biophysics
- Том: 521
- Год издания: 2025
- Издательство: M A I K Nauka - Interperiodica
- Местоположение издательства: Russian Federation
- Первая страница: 165
- Последняя страница: 168
- DOI: 10.1134/S1607672924601240
- Аннотация: Previously, polypeptide constructs—modular nanotransporters (MNTs)—were created to deliver biologically active molecules into the nuclei of melanoma cells. In the present work, polyethylene glycol (PEG) molecules were attached to them at the N-terminal cysteine, both with the possibility of their subse- quent cleavage at the hydrolysis site of tumor-specific proteases, and without this site (non-detachable PEG). All MNT variants labeled with the radioisotope 111In were administered to mice with inoculated Cloudman S91 melanoma. The kinetics of radioactivity distribution in the mouse body was studied using single-photon emission computed tomography. Analysis of the obtained data using a compartmental mathematical model allowed us to establish that the attachment of PEG to MNT increased its lifetime in the blood and signifi- cantly increased its accumulation in the tumor. Addition of a PEG detachment site by tumor-specific prote- ase led to a strong retention of this MNT in the tumor. The data obtained can serve as a basis for the creation of new effective antitumor drugs.
- Добавил в систему: Соболев Александр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Khramtsov_et_al_Doklady_2025_521_pp_165168.pdf | 302,5 КБ | 10 мая 2025 [Sobolev] |