Synthetic Utilization of Polynitro Aromatic Compounds. 5. Multi-Centered Reactivity Pattern in Reactions of 4,6-Dinitro-1,2-benzisothiazoles and -isothiazol-3(2H)-ones with C-, N-, O-, S-, and F-Nucleophilesстатья
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Дата последнего поиска статьи во внешних источниках: 17 ноября 2014 г.
Аннотация:Reactions of 4,6-dinitro-1,2-benzisothiazoles, -isothiazol-3(2H)-ones, and -isothiazol-3(2H)-one-1-oxides with C-, N-, O-, S-, and F-nucleophiles give products of aromatic nucleophilic substitution of one or two nitro groups, “vicarious” substitution of the hydrogen atom H-7, or heterocyclic S-N bond cleavage depending on the structure of the starting compound and the nature of the nucleophile. These reactions provide a new synthetic approach to a family of biologically active benzisothiazol-3(2H)-ones based on 2,4,6-trinitrotoluene (TNT).