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Donor‐Acceptor (Perylenethienyl)Ethylenes as Singlet Oxygen‐Photogenerating Viral Inhibitors**статья
- Авторы: Krasilnikov Maxim S., Mazur Roman V., Chumakov Stepan P., Denisov Vladislav S., Goldenberg Efim A., Nikolaenko Yan I., Bersenev Evgeny A., Nikitin Timofei D., Orinicheva Polina S., Brylev Vladimir A., Gulyak Evgeny L., Korshun Vladimir A., Alferova Vera A., Gvozdev Daniil A., Ustinov Alexey V.
- Журнал: Chembiochem : a European journal of chemical biology
- Том: 26
- Номер: 7
- Год издания: 2025
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- DOI: 10.1002/cbic.202401019
- Аннотация: The development of broad-spectrum antiviral drugs effective against a wide range of viruses is of significant practical importance. Derivatives of perylene, a pentacyclic aromatic hydrocarbon, demonstrate pronounced antiviral activity. These compounds act primarily as membrane-active singlet oxygen photogenerators, disrupting virions and inhibiting their fusion with the host cell membrane. Modification of the perylene core allows for chemical diversification of antiviral photosensitizers. Additionally, achieving a bathochromic shift of the absorption band is crucial for effective treatment of superficial lesions, as it facilitates deeper tissue penetration of therapeutic light. In this work, donor-acceptor perylenylethylenes and (perylenethienyl)ethylenes were synthesized and evaluated for their spectral properties, singlet oxygen photogeneration, and inhibitory activity against vesicular stomatitis virus (VSV), a representative enveloped virus. Incorporation of a thiophene moiety into the molecule significantly enhanced both the singlet oxygen generation ability and the antiviral activity. These findings provide useful insights into the relationship between the structure, spectral/photochemical properties, and biological activity of perylene-based photosensitizers.
- Добавил в систему: Красильников Максим Сергеевич