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Exploiting Palladium-Catalyzed Cross-Coupling for the Synthesis of 2-Aryl-Substituted 1-Aminocyclopropylphosphonatesстатья
- Авторы: Makukhina Nikolay N., Goulioukina Nataliya S., Bessmertnykh-Lemeune Alla G., Stéphane Brandès, Roger Guilard, Beletskaya Irina P.
- Журнал: SYNTHESIS-STUTTGART
- Том: 47
- Год издания: 2015
- Издательство: Georg Thieme Verlag
- Местоположение издательства: Germany
- DOI: 10.1055/s-0034-1378673
- Аннотация: A series of 2-aryl-substituted 1-aminocyclopropylphosphonates containing an additional remote phosphonate group have been synthesized starting from readily accessible dimethyl (1R*,2R*)-2-(4- bromophenyl)-1-formamidocyclopropylphosphonate using cross-coupling methodology. Different types of palladium-catalyzed reactions for carbon–carbon and carbon–phosphorus bond formation were realized. In each case the optimum conditions were found to obtain the desired products in high yield in both small- and large-scale experiments.
- Добавил в систему: Гулюкина Наталия Сергеевна