Аннотация:Nanosilver (AgNPs) is widely used in various manufacturing sectors, includingagriculture, food processing, and medicine. Many consumer products used in everydaylife release silver either as ions or nanoparticles. Without proper regulation, consumptionof Ag-containing materials will lead to signifi cant risks for ecosystems and humans.Nonspecifi c oxidative stress is considered one of the most serious problems associatedwith nanoparticle toxicity. In this regard, research into the use of antioxidant drugs toprevent and protect against the negative consequences caused by exposure to Ag NPson the body is promising. The purpose of this work was to evaluate the effect of theantioxidant drug Mexidol on the motor behaviour of rats that received daily Ag NPS withdrinking water. For two weeks, rats in the 1 experimental group received an aqueoussolution with 10-12 nm particles added to their drinking water. The daily dose of Ag NPswas 15.75 mg/kg. The second group of rats additionally received Mexidol, an antioxidantdrug, intraperitoneally at a dose of 10 mg/kg as a 0.5% solution twice daily. All animalswere tested in an Open Field (OF) on the fi rst and 15th day of the experiment. During thefi nal testing in the OF, urine samples were collected from the rats using dry chemistry teststrips. Rats receiving Ag NPs in their drinking water for two weeks urine analysis revealedsignifi cant impairment of renal function. Chronic exposure to Ag NPs can negativelyimpact fundamental behavioural patterns in rats, particularly their stress responses andlocomotor activity. In 1 group of rats defi ned a decrease in locomotor activity and anincrease in anxiety-like behaviour compared to the fi rst day of the experiment. In ratsadditionally receiving Mexidol injections, the drug improved exploratory behaviour andreduced emotional responses.
