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Expression of the tumor necrosis factor locus is not necessary for the cytolytic activity of T lymphocytesстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 января 2015 г.
- Авторы: Jongeneel CV, Nedospasov SA, Plaetinck G., Naquet P., Cerottini JC
- Журнал: Journal of Immunology
- Том: 140
- Номер: 6
- Год издания: 1988
- Издательство: American Association of Immunologists
- Местоположение издательства: United States
- Первая страница: 1916
- Последняя страница: 1922
- Аннотация: In order to test whether tumor necrosis factors alpha (TNF-alpha) or beta (TNF-beta, also known as lymphotoxin) are involved in the lysis of target cells by cytolytic T lymphocytes, we probed for the presence of the TNF mRNAs in several quiescent and activated CTL clones. No TNF mRNA could be found in constitutively cytolytic Lyt-2+ clones, and only two out of three clones tested accumulated TNF mRNA after stimulation with phorbol myristate acetate and ionomycin. Of two L3T4+ clones that can be induced to become cytolytic by a combination of antigen and IL-1, only one accumulated TNF-beta mRNA in the process. The PC60 rat X mouse T cell hybrid, which becomes cytolytic in response to a combination of IL-1 and IL-2, also failed to accumulate TNF mRNA after stimulation with these agents. Our results strongly suggest that TNF-alpha or -beta are not necessary agents of the cytolytic activity exhibited by antigen-specific T lymphocytes.
- Добавил в систему: Несмиянов Павел Павлович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 10.0000www.jimmunol.org14061916.pdf | 4,1 МБ | 26 декабря 2014 [Pecatum] |