|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Preparation of pH‑tunable polyelectrolyte complexes of alginate sodium salt and N‑[(2‑hydroxy‑3‑trimethylammonium) propyl] chitosan chlorideстатья
- Авторы: Gorshkova Marina, ·Irina Volkova
- Журнал: Journal of Polymer Research
- Том: 28
- Год издания: 2021
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 94
- Аннотация: AbstractStimuli-response polymer formulation are of great interest for medicine application. Polyelectrolyte complexes due totheir unique ability to change the properties under the external factors represent an example of systems with the feedbackmechanism. Interaction of N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) and alginate sodiumsalt (ASS) was studied in order to design the stimuli-response complexes. The pH value was found to be one of the mostimportant parameters governing the phase separation in the mixtures of water salt solutions of HTCC and ASS as well as theproperties of the resulting complexes. The negatively charged nanoparticles were characterized by the unimodal distributionand had the average sizes 170 ÷ 500 nm depending of composition and pH value; positively charged particles with unimodaldistribution were formed only in slightly acidic media. The obtained complexes were stable against the destructive actionof salt higher than physiological one. The data demonstrated the potential of the complexes as a promising platform fordevelopment of biocompatible, biodegradable and pH-tunable drug delivery systems. Preparation of complexes based onpolymers able to undergo pH-dependent ionization with desired properties requires consideration of all factors, ratio of thecomponents and their molecular mass, medium pH and salt concentration.
- Добавил в систему: Волкова Ирина Федоровна