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Chemoinformatic Approach to Identify Antiviral Components of Humic Substancesтезисы доклада
- Авторы: Osolodkin Dmitry I., Orlov Alexey A., Zherebker Alexandr Y., Kozlovskaya Liubov I., Perminova Irina V.
- Сборник: Book of Abstracts. Fourth International Conference of CIS IHSS on Humic Innovative Technologies «From Molecular Analysis of Humic Substances – to Nature-like Technologies» (HIT-2017)
- Тезисы
- Год издания: 2017
- Место издания: ООО "КЛУБ ПЕЧАТИ" Москва
- Первая страница: 34
- Последняя страница: 35
- Аннотация: Humic substance (HS) is a heterogeneous supramolecular ensemble of natural organic compounds formed by oxidative decomposition of biomacromolecules in soils, coals, waters, etc. It has a broad spectrum of biological activity, such as anti-inflammatory, antibacterial, and antiviral. Inhibitory effect of HS on reproduction of a wide range of DNA and RNA viruses reveals a possibility to apply HS against human pathogens with no approved therapeutics. However, the exact structural composition of HS can not be determined by modern analytical techniques and structure and the nature of HS bioactivity remains unknown, thus complicating the process of development HS-based drugs. In this study we investigated inhibitory effect of ten HS samples, obtained by standard protocols, on enteroviruses and flaviviruses in cell-based assays and developed a technique for an active component identification using high-resolution mass-spectrometry spectral data analysis and chemical database search.
- Добавил в систему: Жеребкер Александр Яковлевич