|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Role of mitochondria and network connectivity in intercellular calcium oscillationsстатья
- Авторы: Dokukina IV, Gracheva M.E., Grachev E.A., Gunton J.D.
- Журнал: arXiv:physics
- Том: 2
- Номер: 0509062
- Год издания: 2006
- Первая страница: 1
- Последняя страница: 34
- Аннотация: Mitochondria are large-scale regulators of cytosolic calcium (Ca2+) under normal cellular conditions. In this paper we model the complex behavior of mitochondrial calcium during the stimulation of a single cell by increase of agonist generated inositol 1,4,5-trisphosphate (IP3) concentration and find results that are in good agreement with recent experimental studies. We also study the influence of the cellular network connectivity on intercellular calcium signaling via gap junction diffusion of second messengers. We include in our model the dependence of the junctional conductivity on the cytosolic calcium concentrations in adjacent cells. We consider three different mechanisms of calcium wave propagation through gap junctions: via Ca2+ diffusion, IP3 diffusion, and both Ca2+ and IP3 diffusion. Our results suggest that IP3 diffusion is the mechanism of Ca2+ wave propagation and that Ca2+ diffusion is the mechanism of synchronization of cytosolic Ca2+ oscillations in adjacent cells. We also study the role of different topological configurations of cellular connectivity on these phenomena. We argue that the most important issue in modelling the intercellular calcium signaling is to account for the cellular topology of the tissue. Our results suggest that the dynamics of the tissue is defined by the topology of the connection graph of cells with each other. Key words:Calcium wave, calcium signaling, inositol 1,4,5-trisphosphate, mitochondrion, gap junction, network, connectivity, topology.
- Добавил в систему: Грачев Евгений Александрович