Synthesis and reactivity of new amide-substituted oxindole derivatives

Zaryanova, E.V.; Ignatov, A.A.; Lozynskaya, N.A.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 декабря 2017 г.

Авторы: Zaryanova E.V., Ignatov A.A., Lozynskaya N.A.
Журнал: Tetrahedron
Том: 73
Год издания: 2017
Издательство: Pergamon Press Ltd.
Местоположение издательства: United Kingdom
Первая страница: 6887
Последняя страница: 6893
DOI: 10.1016/j.tet.2017.10.049
Аннотация: Oxindole derivatives are of growing importance in organic synthesis and in the synthesis of biologically active compounds, therefore, a very important goal is to develop new ways of modifying such scaffold. In this article we proposed a general approach to synthesis of oxindole-based amide-substituted compounds, which includes usage of protecting group. To stabilize the key-molecule for further modifications - amino-isatin, the carbonyl group in the 3-position of the starting nitro-isatin was protected by ketal synthesis. Next, the reduction of nitro-group and further modification of amino-group was carried out. The proposed strategy allows us to obtain mono- and diamido-substituted isatins. The possibility of their modification in the 3-position for synthesis of potent biologically active compounds is demonstrated.
Добавил в систему: Зарянова Екатерина Витальевна

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ИНХС РАН

Synthesis and reactivity of new amide-substituted oxindole derivativesстатья

Прикрепленные файлы