Study of the fullerene C60 stability in biological substrates using in vitro model systemстатья
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Дата последнего поиска статьи во внешних источниках: 19 сентября 2015 г.
Аннотация:This paper presents the results of an in vitro study of the unmodified fullerene C60 stability in samples of biological substrates obtained from Wistar rats. The known amounts of fullerene C60 at various concentrations are added to the freshly prepared samples of rat whole blood, homogenates, and liver microsomal fractions; the decrease in its concentration over a day is studied using HPLC. The data testify to the instability of fullerene C60 in biological media in situations reproducing with some degree of approximation the processes of biodegradation of the substance taking place in a living organism (nitrogen-oxygen atmosphere, +37°C, in the dark).