|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
NEW EEG MARKERS OF PARKINSON'S DISEASE AS REVEALED THROUGH THE AUTHOR'S METHOD - "MICROSTRUCTURAL ANALYSIS OF OSCILLATORY BRAIN ACTIVITY"тезисы доклада
- Авторы: Danilova N.N., Hodel M.R., Yakhno N.N.
- Сборник: In t e r n a t i o n a l C o n g r e s s “Neuroscience for Medicine and Psychology” Sudak, Crimea, Russia, May 30–June 10, 2017
- Том: 13
- Тезисы
- Год издания: 2017
- Место издания: Moscow, Instetute of Higher Nervous Activity and Neurophysiology of RAS Russia
- Первая страница: 143
- Последняя страница: 144
- Аннотация: NEW EEG MARKERS OF PARKINSON'S DISEASE AS REVEALED THROUGH THE AUTHOR'S METHOD - "MICROSTRUCTURAL ANALYSIS OF OSCILLATORY BRAIN ACTIVITY". Danilova N.N.1, Nodel М.R.2, Yakhno N.N.2 1 Department of Psychology, Lomonosov Moscow State University, Moscow, Russia 2. Department of Neurology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. danilovan@mail.ru The aim of this work is to study of the cognitive processes in two patient groups with Parkinson's disease (PD) and then to identify the earliest cognitive markers for this disease. The author's method - "Microstructural analysis of oscillatory brain activity" (Danilova, 2002), which is based on the pacemaker hypothesis of the rhythmogenesis, was used to study the cognitive disorders in patients with Parkinson's disease. In the processing of PD development it was revealed the increasing of latent period of motor reaction during the identification of the category "animals". We don‘t found these changes during the identification of category of "objects". These results were obtained for two groups of patients with PD. Patients of group 1 (11 people, 4 men and 7 women, aged 64-79 years, 1 to 3 upon Hoehn-Yahr scale) were on monotherapy - drug (levodopa). Patients of group 2 (11 patients, 6 men and 5 women, ages 47-68, 1 to 2 upon Hoehn-Yahr scale) took dopamine receptor agonists and were at an earlier stage of PD. The absence of cognitive impairment and limitation in the shaking function was in all patients.The control group is consisted of 10 people (5 men and 5 women, age 48-68 years). Each group of patients was evaluated by the difference in latent periods for the two categories of stimuli. Then this date were compared with latent periods obtained for the norm group. Reducing the differences between latent periods for the two categories ("animals" and "objects") are most pronounced in the 1-st group of patients (36,8061), and with lesser extent in the 2-nd group of patients (48,1786). The greatest differences of the latent period of motor reactions during the identification of two stimuli categories was found in the norm group (85, 6879). The differences are statistically significant. Reducing the differences between the latent periods obtained for two categories: "animals" and "objects", incentives can be considered as a new marker for Parkinson's disease, reflecting the violation of sm, connected with identification of the сategory "animals". Previously we have shown reaction of anticipation that appears before the more difficult task. We have confirmed that reaction of the anticipation as a special kind of memory occurs in the normal groups before the category - "objects". But in the patients with PD this reaction appears before category «animals» - as before more complex task. The reaction of the anticipation is the earliest marker for Parkinson's disease. This work was supported by grant RSF № 14-18-03253 П
- Добавил в систему: Данилова Нина Николаевна