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New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 3 декабря 2017 г.
- Авторы: Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P., Myronovskyi M., Zotchev S.B., Rückert C., Braig S., Zahler S., Kalinowski J., Luzhetskyy A.
- Журнал: Scientific reports
- Номер: 7
- Год издания: 2017
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 42382
- DOI: 10.1038/srep42382
- Аннотация: Marine actinobacteria are drawing more and more attention as a promising source of new natural products. Here we report isolation, genome sequencing and metabolic profiling of new strain Streptomyces sp. MP131-18 isolated from marine sediment sample collected in the Trondheim Fjord, Norway. The 16S rRNA and multilocus phylogenetic analysis showed that MP131-18 belongs to the genus Streptomyces. The genome of MP131-18 isolate was sequenced, and 36 gene clusters involved in the biosynthesis of 18 different types of secondary metabolites were predicted using antiSMASH analysis. The combined genomics-metabolics profiling of the strain led to the identification of several new biologically active compounds. As a result, the family of bisindole pyrroles spiroindimicins was extended with two new members, spiroindimicins E and F. Furthermore, prediction of the biosynthetic pathway for unusual α-pyrone lagunapyrone isolated from MP131-18 resulted in foresight and identification of two new compounds of this family - lagunapyrones D and E. The diversity of identified and predicted compounds from Streptomyces sp. MP131-18 demonstrates that marine-derived actinomycetes are not only a promising source of new natural products, but also represent a valuable pool of genes for combinatorial biosynthesis of secondary metabolites
- Добавил в систему: Костина Наталья Викторовна