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Solution Structures of PPAR gamma 2/RXR alpha Complexesстатья
- Авторы: Osz Judit, Pethoukhov Maxim V., Sirigu Serena, Svergun Dmitri I., Moras Dino, Rochel Natacha
- Журнал: PPAR Research
- Том: 8
- Год издания: 2012
- Издательство: Hindawi Publishing Corporation
- Местоположение издательства: United States
- DOI: 10.1155/2012/701412
- Аннотация: PPAR gamma is a key regulator of glucose homeostasis and insulin sensitization. PPAR gamma must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1 alpha to regulate gene networks. To understand how coactivators are recognized by the functional heterodimer PPAR gamma/RXR alpha and to determine the topological organization of the complexes, we performed a structural study using small angle X-ray scattering of PPAR gamma/RXR alpha in complex with DNA from regulated gene and the TIF2 receptor interacting domain (RID). The solution structures reveal an asymmetry of the overall structure due to the crucial role of the DNA in positioning the heterodimer and indicate asymmetrical binding of TIF2 to the heterodimer.
- Добавил в систему: Петухов Максим Владимирович