CHANGES IN THE ELECTRICAL PROPERTIES OF THE SKIN EXTERNAL LAYER DURING PULSE ELECTROTREATMENTстатья
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Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
Аннотация:The kinetics of changes in the electrical current I(t) passing through human skin samples of full thickness in vitro during rectangular voltage pulses (amplitude, 10-60 V; duration; 5-8 ms) was investigated. It was shown that the function I(t) rapidly decreases, passes through its minimum, and then slowly increases. With the increase in voltage, the minimal current value increases; the dropping branch becomes less expressed (up to complete disappearance at 40 V); and the position of the minimum is shifted to short times. All these features of the current response was explained in assumption that electrical properties of the skin at a voltage less than 30 V are determined by macropores of skin appendages (hair follicles, sweat glands, etc.). The dropping branch of the current is a superposition of a charging current of the macropore wall capacity and conductivity current through the electroporated walls. At voltages over 30 V, increases in current and conductivity are determined by electroporation of the lipid-comeocyte matrix of the skin external layer (Stratum Corneum). The kinetics of skin resistance restoration after pulse electrotreatment was also investigated. The characteristic time of restoration, which does not exceed 1 min at 10 V, increases up to dozens of minutes at voltages above 30 V. A close similarity of the investigated phenomena to the electroporation of flat lipid bilayers and plasmatic membranes of isolated cells was found out.