The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animalsстатья Исследовательская статья

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Дата последнего поиска статьи во внешних источниках: 8 декабря 2017 г.

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[1] The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals / I. A. Arkhipov, K. M. Sadov, Y. V. Limova et al. // Veterinary Parasitology. — 2017. — Vol. 246. — P. 25–29. Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery was studied in hymenolepiosis of mice and monieziosis of sheep. The efficacy of new substances of niclosamide with polyvinylpyrrolidone polymer in different ratios (1:10; 1:5; 1:2) was determined by the results of helminthological necropsy of the small intestine of sheep and mice. Pre-treatment eggs per gram (EPG) were not significantly different (P > 0.1) among groups. The controlled test was used to evaluate the efficacy. A high efficacy (> 95% efficacy) of the supramolecular complexes of niclosamide with PVP (SCoNwPVP) was shown in different ratios (1:10; 1:5 and 1:2) at a dose of 20 mg/kg of body weight at oral administration against Hymenolepis nana in mice and Moniezia expansa in sheep. Whereas the basic drug − substance of niclosamide was effective at a dose of 100 mg/kg of b/w. No adverse effects of the drugs on animal health were detected during the study. 1. Introduction Cestodoses of animals are widespread and prevalence of infection of animals ranges from 60 to 100% in some regions of the Russian Federation (Akbayev, 1983; Magomedov, 2000; Belova, 2011). Anoplocephalatosis and especially monieziosis of animals cause significant losses of production because of high prevalence and mortality of young infected animals (Tsoloev, 1999; Chetvertnov et al., 2009). Lambs are more susceptible and massive infections can cause diarrhea, reduced weight gain and intestinal obstruction. It was determined that the body weight gain of the infected lamb is 1.62 times less than the body weight of a healthy animal when calculating the economic damage in monieziosis of sheep. Infection with Moniezia expansa was associated with reduced weight gain estimated at 4.16 kg, with reduced wool yield estimated at 0.42 kg and mortality was 7.1% per animal (Safiullin, 1997). Niclosamide (syn.: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2 hydroxybenzamide, monsonil, fenasal, yomezan) is a chlorinated salicylanilide anthelmintic that is used to treat tapeworm infection in a. [ DOI ]

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