The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animalsстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 8 декабря 2017 г.
Аннотация:Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals. The efficacy of the
supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery was
studied in hymenolepiosis of mice and monieziosis of sheep. The efficacy of new substances of niclosamide with
polyvinylpyrrolidone polymer in different ratios (1:10; 1:5; 1:2) was determined by the results of helminthological
necropsy of the small intestine of sheep and mice. Pre-treatment eggs per gram (EPG) were not significantly
different (P > 0.1) among groups. The controlled test was used to evaluate the efficacy. A high
efficacy (> 95% efficacy) of the supramolecular complexes of niclosamide with PVP (SCoNwPVP) was shown in
different ratios (1:10; 1:5 and 1:2) at a dose of 20 mg/kg of body weight at oral administration against
Hymenolepis nana in mice and Moniezia expansa in sheep. Whereas the basic drug − substance of niclosamide
was effective at a dose of 100 mg/kg of b/w. No adverse effects of the drugs on animal health were detected
during the study.
1. Introduction
Cestodoses of animals are widespread and prevalence of infection of
animals ranges from 60 to 100% in some regions of the Russian
Federation (Akbayev, 1983; Magomedov, 2000; Belova, 2011). Anoplocephalatosis
and especially monieziosis of animals cause significant
losses of production because of high prevalence and mortality of young
infected animals (Tsoloev, 1999; Chetvertnov et al., 2009). Lambs are
more susceptible and massive infections can cause diarrhea, reduced
weight gain and intestinal obstruction. It was determined that the body
weight gain of the infected lamb is 1.62 times less than the body weight
of a healthy animal when calculating the economic damage in monieziosis
of sheep. Infection with Moniezia expansa was associated with
reduced weight gain estimated at 4.16 kg, with reduced wool yield
estimated at 0.42 kg and mortality was 7.1% per animal (Safiullin,
1997).
Niclosamide (syn.: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2 hydroxybenzamide,
monsonil, fenasal, yomezan) is a chlorinated
salicylanilide anthelmintic that is used to treat tapeworm infection in a