Аннотация:Laboratory diagnostics of sepsis need to be
improved. There is no evidence in the literature whether microbial
metabolites could be used as sepsis markers. As a result of largescale
screening of microbial compounds we showed that levels of
some phenylcarboxylic acids (PCAs) were increased in blood of
septic patients. The content of p-hydroxyphenyllactic acid (HPLA),
phenyllactic acid (PLA) and p-hydroxyphenylacetic acid (HPAA)
was significantly higher in blood of patients with severe sepsis
compared with control groups. The aim of the present study is to
evaluate the sensitivity and specificity of PLA, HPLA and HPAA as
markers for severe sepsis diagnostics.