Ernst Schering Research Foundation Workshop 57. The Histone Code and Beyond. New Approaches to Cancer Therapy. 2006;(57):89-96, Название главы: How is epigenetic information on chromatin inherited after DNA replication?

Nakatani, Y.; Tagami, H.; Shestakova, E.

Авторы: Nakatani Y., Tagami H., Shestakova E.
Год издания: 2006
Издательство: Springer Berlin
Местоположение издательства: Heidelberg, Germany
Объём: 8 страниц
ISBN: 3-540-27857-5
Монография
Академическое издание
DOI: 10.1007/3-540-37633-x_5
Аннотация: Although most somatic cells have identical genetic information, gene expression profiles are quite distinct in each cell type. The gene expression profiles are considered to be determined mainly by chromatin-encoded epigenetic information that includes histone modifications, histone variants, and factors such as HP1 and polycomb group proteins that organize higher-ordered chromatin structures. To gain insights into how such epigenetic information on chromatin is inherited on daughter DNA strands after DNA replication, we have purified the preassembled form of histone H3 by immunoaffinity purification. The histone H3 complex contains the two histone H3-H4 chaperones CAF1 and ASF1. Surprisingly, the H3 complex also contains a pair of H3-H4 dimers. This observation is striking because histones H3-H4 are known to exist as tetramers in solution. Since histones H3-H4 in the predeposition complex exist as a dimer, this raises the possibility that the H3-H4 dimer in the complex pairs with a parental H3-H4 dimer, assembling the de novo-synthesized and parental H3-H4 dimers in the same nucleosome. Based on these results, we propose a semi-conservative model of nucleosome duplication, which allows for segregation of parental H3-H4 dimers with encoded epigenetic information evenly to daughter DNA strands.
Добавил в систему: Шестакова Елена Анатольевна

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Ernst Schering Research Foundation Workshop 57. The Histone Code and Beyond. New Approaches to Cancer Therapy. 2006;(57):89-96, Название главы: How is epigenetic information on chromatin inherited after DNA replication?книга

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