Mesenchymal Stem Cell Therapy for Inflammatory Bowel Disease

Konoplyannikov, M.; Knyazev, O.; Timashev, P.; Baklaushev, V.

Авторы: Konoplyannikov Mikhail, Knyazev Oleg, Timashev Peter, Baklaushev Vladimir
Год издания: 2022
Издательство: Springer Singapore
Местоположение издательства: Singapore
Объём: 28 страниц
DOI: 10.1007/978-981-16-6016-0_8-1
Аннотация: Inflammatory bowel disease (IBD) belongs to the group of diseases characterized by idiopathic inflammation of the gastrointestinal organs. Two basic IBD types are distinguished: ulcerative colitis and Crohn’s disease. The IBD symptoms including vomiting and diarrhea, abdominal pain, rectal hemorrhage, and anemia have a significant negative impact on the general patient’s state of health. More than four million people in the USA and Europe suffer from IBD, while the general incidence of this disease in the developed countries exceeds 0.5% of the population. Besides, IBD is associated with a significant risk of colitis-associated malignancy. In the last decades, considerable progress has been achieved in the IBD therapy due to application of drugs suppressing the local gastrointestinal tract inflammation, such as antibodies to TNF-α (infliximab and adalimumab), corticosteroids, salicylates, etc. At the same time, this strategy, unfortunately, does not result in the repair of the damaged tissues, primarily ulcers of the colon, in many IBD patients. To achieve the mucosa healing and stable remission in IBD patients, novel approaches are required, cell therapy, actively used since the beginning of 2000s, being one of them. In our book chapter, we discuss the advantages and problems of application of mesenchymal stem cells (MSCs) which are most actively used in the cell therapy of IBD. The results of the most important preclinical and clinical studies are covered.
Добавил в систему: Тимашев Петр Сергеевич

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