ИСТИНА

Chiral Brønsted acid catalysis is an emerging area of organocatalysis. Mannich-type reactions, numerous catalytic asymmetric transformations involving imine activation have been realized by means of this catalyst class, including among others cycloaddition reactions, transfer hydrogenations, and reductive aminations.The most of known corresponding organocatalysts are derivatives of phosphoric or carboxylic acids with chiral condensed aromatic backbone. New non-racemic Brønsted acids containing carboxylic acid site in different asymmetric β-peptide environment were synthesized using cycloadditive oligomerization approach. These compounds were obtained by the acid hydrolysis of corresponding tert-butyl esters and will be investigated as new chiral organocatalysts.