ИСТИНА

The complexity and power of modern computer information systems is astonishing, rivalling the complexity of living organisms - the most sophisticated entities nature has created. Yet, our understanding of how living systems function at the molecular level remains elusive. The information content of the genetic programs encoded by the DNA in human genome is less than 900 megabytes and has been known for two decades to date. However, understanding the molecular mechanisms underlying the interpretation of these programs is a big challenge of this century. The growing capabilities of modern computer systems and algorithms are an ultimately required component for addressing this challenge. In this talk I will showcase how supercomputer simulations allow us to gain insights into the molecular mechanisms of DNA functioning in living systems by understanding its dynamic interactions with proteins.