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Pyrazole derivatives belong to aromatic heterocyclic compounds which are widely used in synthetic organic and medicinal chemistry. Ortho-substituents in aryl azides play significant role in reducing the energy barrier for the formation of nitrenes due to the appearance of cyclic transition states. Azidopyrazoles are precursors for the synthesis of biologically active small molecule inhibitors of factor Xa, which plays a central role in the blood coagulation cascade.
№ | Имя | Описание | Имя файла | Размер | Добавлен |
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1. | Сборник тезисов | DIAZO_2021_BOOK_OF_ABSTRACTS.pdf | 18,0 МБ | 26 октября 2021 [assachembai] |