ИСТИНА

Antidiabetic effect of complex 1 was carried out in an in vitro study. It was found that complex 1 acts on the therapeutic targets of T2DM: it inhibits the processes of lipid peroxidation (IC 50 = 0.4 mM) and non-enzymatic glycosylation of albumin protein (IC 50 = 47.4 ± 7.6 µM), also reduces the catalytic activity of the aldose reductase: enzyme of the polyol pathway of glucose metab- olism (K i = 5.25∙10 -4 M). We present for the fi rst time that one of the mechanisms of the antioxidant action of complex 1 is its ability to scavenge free radicals due to NO donation. The data obtained indicate the prospects for further study of iron nitrosyl complexes in order to create a new class of ef- fective drugs for treatment of T2DM and its complications.