ИСТИНА

Red blood cells (RBCs) are the primary cellular elements of blood performing several important functions in the body. RBCs are able to reversibly form 2D or 3D structures (aggregates), which significantly influence the blood circulation in the body. Studying the aggregation properties of erythrocytes is an essential task because it can provide insight into the state of blood and its ability to effectively transport oxygen. Aggregation properties of erythrocytes can change due to various factors, such as alterations in the protein composition of blood [1] and diseases [2]. However, currently, information about RBCs aggregation in patients of different age groups is limited. Therefore, investigating age-related changes in RBCs aggregation properties is an important task in assessing blood microcirculation. The main goal of this work is to study the aggregation properties of erythrocytes in patients of different age groups suffering from arterial hypertension (AH) and atrial fibrillation (AF), as well as in healthy donors. [1] Semenov A.N., Lugovtsov A.E., Li K., Fabrichnova A.A., Kovaleva Y.A., Priezhev A.V. "The use of methods of diffuse light scattering and optical trapping to study the rheological properties of blood: erythrocyte aggregation in diabetes" // Izvestiya of Saratov University. New Series. Series Physics, 2017, Vol. 17, No. 2, pp. 91-94 (in Russian). [2] Korneev K.N., Ermolinsky P.B., Lugovtsov A.E., Priezzhev A.V. "Comparison of the influence of fibrinogen and gamma-globulin on erythrocyte aggregation in vitro" // Collection of materials of the international internet symposium "MICROCIRCULATION, BLOOD RHEOLOGY, AND OXYGEN HOMEOSTASIS", Yaroslavl’, 2022, pp. 229 – 235 (in Russian).