Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stressстатья
Статья опубликована в высокорейтинговом журнале
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 сентября 2015 г.
Аннотация:Heat stress is one of the best-studied cellular stress
factors; however, little is known about its delayed effects.
Here, we demonstrate that heat stress induces
p21-dependent cellular senescence-like cell cycle
arrest. Notably, only early S-phase cells undergo
such an arrest in response to heat stress. The encounter
of DNA replication forks with topoisomerase
I-generated single-stranded DNA breaks resulted in
the generation of persistent double-stranded DNA
breaks was found to be a primary cause of heat
stress-induced cellular senescence in these cells.
This investigation of heat stress-induced cellular
senescence elucidates the mechanisms underlying
the exclusive sensitivity of early S-phase cells to
ultra-lowdoses of agents that induce single-stranded
DNA breaks