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Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stressстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 сентября 2015 г.
- Авторы: Velichko Artem K., Petrova Nadezhda V., Razin Sergey V., Kantidze Omar L.
- Журнал: Nucleic Acids Research
- Том: 43
- Номер: 13
- Год издания: 2015
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 6309
- Последняя страница: 6320
- DOI: 10.1093/nar/gkv573
- Аннотация: Heat stress is one of the best-studied cellular stress factors; however, little is known about its delayed effects. Here, we demonstrate that heat stress induces p21-dependent cellular senescence-like cell cycle arrest. Notably, only early S-phase cells undergo such an arrest in response to heat stress. The encounter of DNA replication forks with topoisomerase I-generated single-stranded DNA breaks resulted in the generation of persistent double-stranded DNA breaks was found to be a primary cause of heat stress-induced cellular senescence in these cells. This investigation of heat stress-induced cellular senescence elucidates the mechanisms underlying the exclusive sensitivity of early S-phase cells to ultra-lowdoses of agents that induce single-stranded DNA breaks
- Добавил в систему: Разин Сергей Владимирович